6/20/2023 0 Comments Download glucose structure![]() The full-length protein, which has a canonical major facilitator superfamily fold, is captured in an inward-open conformation. Here we report the crystal structure of human GLUT1 at 3.2 Å resolution. Despite decades of investigation, the structure of GLUT1 remains unknown. Dysfunctional mutations may lead to GLUT1 deficiency syndrome, whereas overexpression of GLUT1 is a prognostic indicator for cancer. The glucose transporter GLUT1 catalyses facilitative diffusion of glucose into erythrocytes and is responsible for glucose supply to the brain and other organs. ![]()
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